That means someone is afraid she may have committed a crime. This issue is no longer about politics, it's now a criminal investigation of the Attorney General of the United States. More from the Washington Post.
More on The Fifth, from FindLaw:
The Fifth Amendment to the U.S. Constitution gives individuals the right to refuse to answer any questions or make any statements, when to do so would help establish that the person committed a crime or is connected to any criminal activity.I do find it ironic that suddenly the Bush Administration has discovered the Bill of Rights.